Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.

• Tác giả: Lena Amenitsch, Christoph Bock, Thomas Decker, Marlies Dolezal, Matthias Farlik, Nikolaus Fortelny, Dagmar Gotthardt, Anzhelika Karjalainen, Milica Krunic, Caroline Lassnig, Therese Lederer, Sabine Macho-Maschler, David Martin, Katrin Meissl, Mathias Müller, Elena Pohl, Michaela Prchal-Murphy, Felix Sternberg, Birgit Strobl, Agnieszka Witalisz-Siepracka
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Cellular and molecular life sciences : CMLS , 2025
• Bộ sưu tập: NCBI
• ID: 741335

Tóm tắt

Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin 12 family responses. Here we relate the transcriptome changes to phenotypical changes observed in TYK2-deficient (Tyk2