Covid-19 pandemic raised both physical and mental threat to human. Globally, 607,497,755cases of infection and 6,492,948 deaths were recorded until August, 2022. The psychosocial-conditions in pre-infection-period might influence disease. Here, we delineate the impact of socio-economic status, pre- or post- Covid-19 psychosocial and other factors (lockdown/self-isolation/diagnosis)on this disease outcome. Pre-Covid mental-status (depression-anxiety, tobacco-smoking and suicide-mortality), quality-of-life (QOL) and Global-Health-Security (GHS) were correlated with total-infection and case-fatality-rate (CFR) in >
170 countries. The database of World-Health-Organization/World-Bank/United-Nations and the Johns-Hopkins-Center for Health-Security was utilized. The Student's t test, multivariate-ANOVA, correlation and linear-regression were performed. Psychological wellbeing indicators (happiness/GSH/QOL) and mental-impairments like depression-anxiety positively correlated with infection and CFR (p <
0.05-p <
0.002). The happiness-index positively associated with QOL/GSH/anxiety and depression. Higher CFR was noticed in congested/populated territories. Canonical regression strongly suggests this result. Variable host-virus interactions associated with race/ethnicity and body-composition. Positive correlations between mental state-QOL and anxiety-depression paralleled with adverse outcome of Covid-19.