2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.

• Tác giả: Can Di, Ruijuan Gao, Wenbo Guo, Ruikun He, Pengyue Hu, Zilu Jin, Kexin Li, Zhongxia Li, Jiayi Liu, Xiaonan Pan, Ce Qi, Fang Sun, Jin Sun, Huayu Tu, Wenjing Yang, Xiaolei Ze, Lintao Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Gut microbes , 2025
• Bộ sưu tập: NCBI
• ID: 741776

Tóm tắt

2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota and immune system. However, the microbiota of infants with atopic dermatitis (AD) often has difficulty utilizing 2'-FL. Here, we found that strains from human milk,