PURPOSE: The aim of this study was to investigate the influence of the simultaneous multislice acceleration (SMS) technique as well as two-dimensional (2D) and three-dimensional (3D) tumor segmentations on radiomics features (RFs) within the parametric maps of cervical cancer, which were computed by intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI). Additionally, the study sought to identify those RFs that could characterize the clinical stages (low-stage vs. high-stage) of cervical cancer. MATERIALS AND METHODS: Multi-b-value diffusion-weighted imaging (DWI) of 40 patients with cervical cancer were collected using the SMS technique with acceleration factors (AF) of 1-3. RFs were extracted from parametric maps representing pure diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), mean diffusivity (MD), and mean kurtosis (MK). A total of 93 2D and 93 3D RFs were extracted from per parametric map. The concordance correlation coefficient (CCC) and coefficients of variation (COV) were used to jointly assess the stability of features. Finally, the intra-class correlation coefficient (ICC) was used for intra-group consistency assessment. Receiver operating characteristic (ROC) curve was used to evaluate diagnostic performance of stable features in distinguishing lower and higher stages. RESULTS: Feature stability decreased with higher AF. Among these features, 9.1% of 2D and 12.7% of 3D RFs were stable (CCC >
0.9 and COV ≤ 0.1). ADC maps had the highest stability, whileas D CONCLUSION: SMS demonstrated impact on the stability of RFs in IVIM and DKI parametric maps, particularly for D* and f maps. Multi-b-value DWI with SMS (AF = 2) was recommended for clinical radiomics research.