Experimental basis for generating nonhuman primate models of frontotemporal dementia and Alzheimer's disease.

• Tác giả: Makoto Higuchi, Takahiro Morito, Hideyuki Okano, Takaomi C Saido, Hiroki Sasaguri, Erika Sasaki, Taisuke Tomita, Naoto Watamura
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.434 Experimental method
• Thông tin xuất bản: United States : Journal of Alzheimer's disease : JAD , 2025
• Bộ sưu tập: NCBI
• ID: 741863
• Chủ đề: 1. Experimental; 2. Basis; 3. For

Tóm tắt

To our knowledge, no reports have described nonhuman primate (NHP) models of frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) that do not depend on an overexpression paradigm. Based on our recent success in generating single human