BACKGROUND: Endovascular treatment (EVT) of intracranial aneurysms (IAs) has improved significantly with the integration of virtual simulation software (VSS) in surgical planning and device selection. Despite promising outcomes, discrepancies remain between physician and VSS recommendations. This review synthesizes evidence on (1) comparisons between VSS-chosen and physician-chosen dimensions
(2) VSS-chosen and postoperative measured dimensions
and (3) the success rate of VSS-guided device deployment. METHODS: A systematic search adhering to PRISMA guidelines was conducted in Medline, Embase, Web of Science, and Cochrane databases up to January 2024. Eligible studies included case series, cohort studies, and randomized trials assessing VSS for stent selection in IAs treatment. Mean difference (MD) and single-arm meta-analysis with 95% confidence intervals (CIs) under a random-effects model were performed for continuous and binary outcomes. Subanalyses were conducted for Sim&Size and PreSize software. RESULTS: Ten studies comprising 658 IAs were included. Pipeline Embolization Device was most commonly used. Findings demonstrated (1) high accuracy of VSS when comparing simulated and postoperative lengths (MD -1.7 mm
95% CI -4.37 to 0.98 mm)
(2) physician-chosen lengths overestimated compared to VSS (MD -2.11 mm
-3.43 to -0.79 mm)
(3) no significant difference in physician- versus VSS-chosen diameters (MD -0.04 mm
-0.13 to 0.06 mm)
and (4) high VSS-guided deployment success (96%
93-99%) with low complications (4%). Subanalyses showed 95% and 92% deployment success rates for Sim&Size and PreSize, respectively. CONCLUSION: VSS effectively estimates device length and achieves high deployment success, with low complication rates, supporting its utility in EVT planning.