Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication.

• Tác giả: Luiza V Barreto, Fernão C Braga, Priscilla R V Campana, Camila Cardoso, Antônio Felipe S Carvalho, Ian de Meira Chaves, Vivian V Costa, Felipe Rocha Silva da Santos, Mariana O de Godoy, Erick Bryan Sousa de Lima, Rafaela S Ferreira, Kátia M Freitas, Rafael V C Guido, Thales Kronenberger, Edvaldo S Lara, Vinícius G Maltarollo, Adelson Héric A Monteiro, Ana Clara M Montuori-Andrade, Natália R C Nóbrega, Glaucius Oliva, Leonardo Camilo Oliveira, Rodrigo M Pádua, Celso M Queiroz-Junior, Maria Beatriz O Rabelo, Filipe Resende, Marina P Rocha, Lirlândia P Sousa, Luiz Pedro Souza-Costa, Mauro M Teixeira, Isabella Zaidan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 354.765284 *Administration of commerce, communications, transportation
• Thông tin xuất bản: England : Phytotherapy research : PTR , 2025
• Bộ sưu tập: NCBI
• ID: 741940

Tóm tắt

Severe coronavirus outbreaks, including SARS, MERS, and COVID-19, have underscored the urgent need for effective antiviral therapies. This study evaluated the antiviral activity of biflavanones isolated from Ouratea spectabilis-specifically ouratein (Our-) A, B, C, and D-against murine hepatitis virus (MHV-3) and human SARS-CoV-2. Cells infected with MHV-3 or SARS-CoV-2 were treated with ourateins, and viral replication was assessed using plaque assays. Mice infected with MHV-3 were treated with Our-D either orally or intraperitoneally. Key assessments included leukocyte counts, cytokine and chemokine levels, histological analysis, and survival rates. The mechanism of action was explored through in silico and in vitro studies focused on the binding and inhibition of the main protease (M