Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers.

• Tác giả: Michael L Alosco, Hugo J Aparicio, Nicholas J Ashton, Rhoda Au, Sarah J Banks, Kaj Blennow, Andrew E Budson, Lindsay A Farrer, Brandon Frank, Lee E Goldstein, Gyungah R Jun, Thomas K Karikari, Jacob Labonte, Brett Martin, Ann C McKee, Jesse Mez, Maureen K O'Connor, Joseph N Palmisano, Erika Pettway, Wei Qiao Qiu, Irene Simkin, Thor D Stein, Eric G Steinberg, Robert A Stern, Michael A Sugarman, Yorghos Tripodis, Katherine W Turk, Henrik Zetterberg
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: United States : Journal of Alzheimer's disease : JAD , 2025
• Bộ sưu tập: NCBI
• ID: 742111

Tóm tắt

BackgroundSex differences have consistently been identified on autopsy, neuroimaging, and cerebrospinal fluid outcomes related to Alzheimer's disease (AD), but the exact mechanisms for these associations are unclear. Blood-based biomarkers are practical alternatives for the investigation of mechanisms of AD, in addition to accurate disease detection and monitoring.ObjectiveThe objective of this study was to examine sex differences across a panel of blood-based plasma biomarkers in participants with and without cognitive impairment due to AD.MethodsPlasma samples were collected from 567 participants from across the AD diagnostic continuum (i.e., normal cognition (NC), mild cognitive impairment (MCI), and dementia) and analyzed for glial fibrillary acidic protein (GFAP), neurofilament light (NfL), phosphorylated tau at threonine 181 (p-tau