Pharmacokinetic approaches to standardize antiviral exposure in cerebrospinal fluid.

• Tác giả: Sean N Avedissian, Ronald J Bosch, Joseph J Eron, Courtney V Fletcher, Rajesh T Gandhi, Jiajun Liu, Caitlyn McCarthy, Deborah K McMahon, John W Mellors, Ying Mu, Anthony T Podany, Serena Spudich
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : Pharmacotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 742115

Tóm tắt

OBJECTIVES: HIV has been shown to persist in the central nervous system (CNS) in persons on antiretroviral therapy (ART). Our objective was to use pharmacokinetic (PK) modeling to estimate cerebrospinal fluid (CSF) exposure from time-variant concentrations of various antiretrovirals of ART regimens and to standardize CSF metrics, including maximum concentration [C METHODS: Advancing Clinical Therapeutics Globally (ACTG) A5321 is a prospective cohort study of HIV-1 reservoirs in persons with HIV. Plasma and CSF antiretroviral (ARV) concentrations were measured in 74 participants who were receiving ART. PK modeling (Pmetrics) was performed for nine ARVs. Relative CSF penetration for each ARV was estimated by comparing CSF C RESULTS: Emtricitabine exhibited the highest median relative CSF penetration (C CONCLUSIONS: PK modeling successfully standardized ARV CSF concentrations to a given time point (i.e., C