Phosphorus (P) and sulphur (S) are essential macronutrients for crop growth, playing critical roles in physiological and biochemical processes throughout the plant life cycle, as well as in mitigating heavy metal and metalloid toxicity. Therefore, the coordinated use of P and S is crucial for optimizing crop growth and reducing the accumulation of heavy metals and metalloids in plants. While P and S signaling pathways are often studied independently, our understanding of their interactions remains limited. A series of recent studies have revealed key components regulating P-S interactions in cereal crops such as rice, maize and wheat, providing new insights into the network that integrates the signaling pathways of P and S. However, the interaction between P and S in molecular regulatory pathways, crop yield improvement, and resistance to heavy metal stress has not yet been systematically summarized or hypothesized. Here, we summarize the latest advances in P-S interactions and propose potential working mechanisms that integrate these P-S interactive regulatory pathways in cereal crops. Furthermore, we discuss the regulatory mechanisms of P-S interactions in cereal crops that still need to be uncovered in the future.