DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson's disease vulnerability.

• Tác giả: Sitong Chen, Chi Cui, Junsong Du, Jie Lei, Ming Li, Tongxia Li, Gangan Luo, Xiang Peng, Kun Ren, Yulong Shi, Bo Tian, Jian Yang, Xueke Yang, Yibo Yao, Pei Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 181.4 *India
• Thông tin xuất bản: England : Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 742525

Tóm tắt

Stress is a recognized risk factor for Parkinson's disease (PD), but the mechanisms by which stress exacerbates PD symptoms through the serotonergic system are not fully understood. This study investigates the role of serotonergic (5-HT) neurons in the dorsal raphe nucleus (DRN) in mediating stress-induced motor deficits and PD progression. Acute and chronic stress were induced in mice using an elevated platform (EP) and combined with MPTP administration to model early-stage PD. Acute EP stress caused transient motor deficits and significant activation of DRN