Spatial and temporal signatures of cell competition revealed by K-function analysis.

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Tác giả: Guillaume Charras, Nathan J Day, Manasi Kelkar, Alan R Lowe, Jasmine Michalowska, Giulia Vallardi

Ngôn ngữ: eng

Ký hiệu phân loại: 575.9 *Animal-like physiological processes

Thông tin xuất bản: United States : Molecular biology of the cell , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 742698

Cell competition is often categorized into mechanical competition, during which loser cell elimination is induced by long-range mechanical effects, and biochemical competition, during which loser cell elimination results from direct cell-cell contacts. Before confluence, proliferation of winner cells has often been hypothesized to govern competition. Conversely, elimination of loser cells is thought to induce cell proliferation in its vicinity. However, causality is challenging to establish. To address this, we compute spatiotemporal signatures of competitive interactions using K-function clustering analysis. For this, we acquire long-term time lapses of two examples of mechanical (Scr
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