Bispecific antibodies targeting MPXV A29 and B6 demonstrate efficacy against MPXV infection.

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Tác giả: Sadia Asghar, Jiayin Chen, Jiahua Kuang, Mengjun Li, Yun Peng, Chenguang Shen, Fungxiang Wang, Yang Yang, Wei Zhao

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Journal of virology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 742996

Recently, the monkeypox virus (MPXV) outbreak was once again declared by the World Health Organization as a global health emergency, and currently, there is no specific drug against MPXV. During the replication cycle, MPXV produces two distinct forms of viral particles: extracellular enveloped virus (EEV), released via exocytosis, and intracellular mature virus (IMV), expelled through host cell lysis. A29 and B6 proteins are membrane proteins found on the IMV and EEV viral particles, respectively. This study designed two different bispecific antibodies (bsAbs) targeting specific antigens of the MPXV: the developed bsAb 9F8-3A1 targets two non-competitive binding epitopes on the MPXV protein A29, while bsAb 9F8-7C9 targets different antigen-binding epitopes on both A29 and B6. The
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