Quantitative in vitro-to-in vivo extrapolation of human adrenergic and trace amine-associated receptor 1 potencies of pre-workout supplement ingredients using physiologically based kinetic modelling-based reverse dosimetry.

• Tác giả: W Matthijs Blankesteijn, Anastasiya Mircheva, Antoon Opperhuizen, Nicole E T Pinckaers, Ans Punt, Frederik-Jan van Schooten, Misha Vrolijk
• Ngôn ngữ: eng
• Ký hiệu phân loại: 577 Ecology
• Thông tin xuất bản: Germany : Archives of toxicology , 2025
• Bộ sưu tập: NCBI
• ID: 743001

Tóm tắt

The present study predicts effective doses of a set of phenethylamine (PEA) analogues that are frequently present in pre-workout and weight-loss food supplements, to prioritize these compounds for further risk assessment. In vitro determined EC