Nanodrug delivery is a critical approach in cancer therapy
however, the deposition of excipients often exacerbates the toxic burden of drugs. Herein, a pillar[5]arene-based supramolecular nanodrug delivery system (WP5⊃C6Py@DOX) has been developed to enhance cancer therapy efficacy while minimizing side effects. This system, constructed through host-guest interactions between a thioether-modified pillar[5]arene derivative (WP5) and a pyridinium salt derivative (C6Py), exhibited a remarkable 97% drug loading capacity for doxorubicin (DOX). It showed remarkable stability in both aqueous solutions and bovine serum, effectively minimizing premature drug leakage and reducing associated toxicity. The thioether modification of WP5 reacted with H