Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling.

• Tác giả: Michael Doherty, Frank J Gonzalez, Cong Hao, Xi Huang, Tingying Jiao, Guanghua Lei, Changjun Li, Hui Li, Jiatian Li, Chuying Sun, Ning Wang, Tingjian Wang, Yilun Wang, Jie Wei, Jing Wu, Cen Xie, Dongxing Xie, Tuo Yang, Yuanheng Yang, Zidan Yang, Chao Zeng, Mengjiao Zhang, Weiya Zhang, Yuqing Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.8232 Subsurface resources
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 743016

Tóm tắt

Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis. Suppressing farnesoid X receptor (FXR)-the receptor of GUDCA-alleviated osteoarthritis through intestine-secreted glucagon-like peptide 1 (GLP-1) in mice. GLP-1 receptor blockade attenuated these effects, whereas GLP-1 receptor activation mitigated osteoarthritis. Osteoarthritis patients exhibited a lower relative abundance of