Vaccine-enhanced competition permits rational bacterial strain replacement in the gut.

• Tác giả: Selma Aslani, Elisa Cappio Barazzone, Médéric Diard, Stefan A Fattinger, Wolf-Dietrich Hardt, Louise Larsson, Verena Lentsch, Claude Loverdo, Claudia Moresi, Andrea Rocker, Niina Ruoho, Emma Slack, Nicolas Wenner, Aurore Woller
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.544 Encampment and field training
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 743019

Tóm tắt

Colonization of the intestinal lumen precedes invasive infection for a wide range of enteropathogenic and opportunistic pathogenic bacteria. We show that combining oral vaccination with engineered or selected niche-competitor strains permits pathogen exclusion and strain replacement in the mouse gut lumen. This approach can be applied either prophylactically to prevent invasion of nontyphoidal