The effect of hippocampal subfield volumes on cognitive decline and incident dementia in a memory clinic cohort.

• Tác giả: Christopher Chen, Saima Hilal, Mervyn Jr Lim, Caroline Robert, Jaclyn Tan, Wei Ying Tan, Narayanaswamy Venketasubramanian
• Ngôn ngữ: eng
• Ký hiệu phân loại: 363.737 Measures to prevent, protect against, limit effects of pollution
• Thông tin xuất bản: United States : Journal of Alzheimer's disease : JAD , 2025
• Bộ sưu tập: NCBI
• ID: 743159

Tóm tắt

BackgroundThe hippocampus plays a central role in cognition and hippocampal atrophy is a key hallmark of Alzheimer's disease. Evidence has suggested associations between hippocampal subfield volumes and specific cognitive domains and dementia risk. However, to our knowledge, no study has examined the role of hippocampal subfield volumes in cognitive decline across different domains over time.ObjectiveWe investigated associations between hippocampal subfield volumes and changes in cognitive domains together with incident dementia in a memory clinic cohort.MethodsAssociations between hippocampal subfield volumes and cognitive decline over three years (