PURPOSE: Bone marrow lesions (BMLs) of the knee are a common magnetic resonance imaging finding and are present in a wide range of pathologies, including traumatic contusions and fractures, following cartilage surgery alterations, osteoarthritis, transient BMLs syndromes, subchondral insufficiency fractures of the knee and spontaneous osteonecrosis of the knee. Regardless of their aetiology, clinical management may prove challenging. This review focuses on the conservative treatment approaches to manage patients affected by knee BML, thanks to the contribution of field experts. METHODS: Experts from around the globe were involved in performing a review on the most used conservative treatment strategies to address BMLs, trying to summarize the available evidence from the most popular first-line treatments while documenting their applications and results for the different BML aetiologies. RESULTS: Positive results were documented for unloading knee braces, external shockwave therapy, hyperbaric oxygen therapy, pulsed electromagnetic fields therapy and bisphosphonates. Nonetheless, the analysis of the scientific literature documented a scarce number of publications specifically addressing the knee joint, with even less evidence when it comes to the results for the different aetiologies of BMLs. CONCLUSION: The management of BMLs is challenging, and many factors influence clinical and radiological outcomes. This paper summarized the evidence on conservative treatments for knee BMLs. Although showing promising results, conservative options still need to be fully investigated. Open questions to be addressed concern treatment duration, BML stage and overlapping with concomitant therapies. Further studies are needed to identify the best first-line conservative approach or treatment combination based on each BML aetiology. LEVEL OF EVIDENCE: Level V: expert opinion.