The Real-World Impact of Glucagon-Like Peptide 1 Receptor Agonists on Asthma Control in People with High-Risk Asthma and Obesity.

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Tác giả: Victoria Carter, Heath Heatley, Richard Hubbard, Alan Kaplan, Mariko Siyue Koh, Tan Tze Lee, David Price, Derek Skinner, John Townend

Ngôn ngữ: eng

Ký hiệu phân loại: 612.665 Climacteric

Thông tin xuất bản: United States : Advances in therapy , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 743315

To quantify the impact of Glucagon-like peptide1 receptor-agonists (GLP1-RAs) on asthma control, we analysed people with asthma and obesity, using the Optimum Patient Care Research Database (OPCRD). We identified 10,111 GLP1-RA exposed people and 50,555 unexposed controls. The exposed cohort had higher BMI and more uncontrolled asthma [risk domain asthma control (RDAC) and overall asthma control (OAC)]. The exposed cohort lost more weight and had improved asthma control for both RDAC (odds ratio 2.11 95% CI 1.90-2.36) and OAC (OR 2.10, 95%CI 1.81-2.45) scores. GLP1-RA drugs appear to improve asthma control for people with obesity.
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