Metformin reduces the competitive advantage of Dnmt3a

• Tác giả: Dhanoop Manikoth Ayyathan, Gary D Bader, Severine Cathelin, Steven M Chan, Ali Chegini, Angelo D'Alessandro, John E Dick, Grace Egan, Samuele Ferrari, Martina Fiumara, Federico Gaiti, Eric Grignano, Mohsen Hosseini, Alex C H Liu, Abdula Maher, Luigi Naldini, Shraddha Pai, Julie A Reisz, Aaron D Schimmer, Jennifer J Trowbridge, Angelica Varesi, Veronique Voisin, Vivian Wang, Yiyan Wu, Stephanie Z Xie, Yitong Yang, Kira Young
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.313 *Form
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 743441

Tóm tắt

Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses