Dynamic adenoma detection rate influences the risk of metachronous advanced neoplasia after removal of low-risk findings in screening colonoscopy.

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Tác giả: Zhiyu Dong, Danian Ji, Feng Li, Ouyang Li, Yanglei Li, Zili Xiao, Shuchang Xu

Ngôn ngữ: eng

Ký hiệu phân loại: 003.85 Dynamic systems

Thông tin xuất bản: Germany : Surgical endoscopy , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 743501

 BACKGROUND: Endoscopists' adenoma detection rate (ADR) may change over time and dynamic ADR has been identified as a predictor for post-screening colorectal cancer. However, whether low-risk findings removed by an endoscopist with a lower dynamic ADR benefit from a shorter duration of follow-up requires further research. METHODS: We conducted a two-center retrospective study of individuals who had low-risk findings removed and underwent subsequent surveillance colonoscopy. Endoscopists' dynamic ADR was the ADR of the previous 100 screening colonoscopies performed by the same endoscopist. A Cox-regression model and Kaplan-Meier survival analysis were used to explore the relationship between dynamic ADR and metachronous advanced colorectal neoplasia (ACRN). RESULTS: Totally, 3471 individuals who had low-risk findings removed in baseline colonoscopy were included in analysis. Decreasing endoscopists' dynamic ADR was independently associated with metachronous ACRN. A 3.97-, 2.21-, and 2.67-fold increased risk for metachronous ACRN was observed in individuals of which baseline colonoscopy was performed by an endoscopist with a dynamic ADR of <
  15%, 15-19%, and 20-24%, respectively, compared with those with the highest dynamic ADR (≥ 25%). The cumulative incidence of metachronous ACRN reached the 5% threshold at 4.5 years, 7.3 years, and 6.2 years in the dynamic ADR <
  15%, 15-19%, and 20-24% group, respectively. CONCLUSION: Endoscopists' dynamic ADR influences the risk of metachronous ACRN after removal of low-risk findings in screening colonoscopy. Individuals undergoing removal of low-risk findings in screening colonoscopy by an endoscopist with a dynamic ADR <
  25% may benefit from a shorter duration of follow-up interval.
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