Diabetes Mellitus and Associated Vascular Disease: Pathogenesis, Complications, and Evolving Treatments.

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Tác giả: Kazi Islam, Rahib Islam, Alan D Kaye, Isabella B Lentz, Hassan Malik, Ivan Nguyen, Humza Pirzadah, Sahar Shekoohi, Barsha Shrestha

Ngôn ngữ: eng

Ký hiệu phân loại: 368.062 Risks to tangible property

Thông tin xuất bản: United States : Advances in therapy , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 743537

Diabetes mellitus is a metabolic disorder, characterized by elevated blood sugar levels (hyperglycemia) and insulin dysregulation. This disease is associated with morbidity and mortality, including significant potential vascular complications. High levels of hyperglycemia lead to not only elevated levels of reactive oxygen species but also advanced glycation end products, which are detrimental to the vascular endothelium and reduce protective compounds such as nitric oxide and prostacyclin. This damage contributes to the development of both macrovascular and microvascular complications. The present investigation explores the pathophysiological mechanisms of diabetic vascular complications and evaluates current management strategies, including lifestyle modifications, pharmacological treatments, and emerging therapies. The review underscores the importance of ongoing progress in diabetes management and patient education to lead to optimal patient-health outcomes and quality of life for individuals with diabetes mellitus.
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