Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.

• Tác giả: Sergio E Baranzini, Florian Beigel, Andrea Flierl-Hecht, Lisa Ann Gerdes, Dirk Haller, Reinhard Hohlfeld, Janine Kövilein, Tanja Kuhlmann, Anneli Peters, Yihui Sun, Jiancheng Wang, Hartmut Wekerle, Hongsup Yoon
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.5266 Astrology
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 743574

Tóm tắt

We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to minimize confounding effects by genetic and early environmental factors and identified over 50 differently abundant taxa with the majority of increased taxa within the