Hyaluronic Acid-Based Nanomotors: Crossing Mucosal Barriers to Tackle Antimicrobial Resistance.

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Valerio Di Carlo, David Esporrín-Ubieto, Noelia Ruiz-González, Samuel Sánchez, Daniel Sánchez-deAlcázar

Ngôn ngữ: eng

Ký hiệu phân loại: 344.046336 Labor, social service, education, cultural law

Thông tin xuất bản: United States : ACS applied materials & interfaces , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 743694

Thêm vào giỏ Liên kết toàn văn

Bacterial infections pose a significant global health challenge aggravated by the rise of antimicrobial resistance (AMR). Among the obstacles preventing effective treatment are biological barriers (BBs) within the body such as the mucus layer. These BBs trap antimicrobials, necessitating higher doses and ultimately accelerating AMR. Addressing this issue requires innovative therapeutic strategies capable of bypassing BBs to deliver drugs more effectively. Here, we present nanomotors (NMs) based on hyaluronic acid (HA)- and urease-nanogels (NGs) as a solution to navigate effectively in viscous media by catalyzing the decomposition of urea into ammonium and carbon dioxide. These HA-based nanomotors (HA-NMs) were loaded with chloramphenicol (CHL) antibiotic and demonstrated superior antimicrobial activity against

1. Hyaluronic
2. Acid
3. Based

Tạo bộ sưu tập với mã QR