Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving

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Tác giả: Zhuo Chen, Masaya Fujita, Oleg A Igoshin, Cristina S D Palma, Brenda Zarazúa-Osorio, Yujia Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 333.822 Coal

Thông tin xuất bản: United States : mSystems , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 743701

UNLABELLED: In starving IMPORTANCE: Cell differentiation is often critical for survival. In bacteria, differentiation decisions are controlled by transcriptional master regulators under transcriptional feedback control. Therefore, understanding how master regulators are transcriptionally regulated is required to understand differentiation. However, in many cases, the underlying regulation is complex, with multiple transcription factor binding sites and multiple promoters, making it challenging to dissect the exact mechanisms. Here, we address this problem for the
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