Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1.

• Tác giả: Puneet Agarwal, Lyndsey Bolanos, John C Byrd, Kwangmin Choi, Jessica Galloway-Pena, David B Haslam, Kathleen Hueneman, Chiharu Ishikawa, Niels Asger Jakobsen, Avery Sampson, Kenneth D Setchell, Daniel T Starczynowski, Emma Uible, Paresh Vyas, Jennifer Yeung, Xueheng Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 262.924 Quinque compilationes antiquae
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 743766

Tóm tắt

Clonal haematopoiesis of indeterminate potential (CHIP) involves the gradual expansion of mutant pre-leukaemic haematopoietic cells, which increases with age and confers a risk for multiple diseases, including leukaemia and immune-related conditions