Gut microbiome and metabolome profiles in renal allograft rejection from multiomics integration.

• Tác giả: Yu Cao, Xing Dai, Yue-Xin Gao, Lin Li, Yao-Juan Liu, Ting-Ting Ma, Zhong-Yang Shen, Jian-Xi Wang, Pan-Pan Zhan, Jian-Ming Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 784.190287 General principles, musical forms, instruments
• Thông tin xuất bản: United States : mSystems , 2025
• Bộ sưu tập: NCBI
• ID: 743781

Tóm tắt

UNLABELLED: The gut microbiome and metabolome play crucial roles in renal allograft rejection progression. Integrated multiomics analyses may provide a comprehensive understanding of specific underlying mechanisms, which remain elusive. This study aimed to identify new approaches for clinical renal allograft rejection diagnosis and treatment. Thirty-five patients were divided into three groups: the rejection ( IMPORTANCE: This study aimed to screen new markers for non-invasive diagnosis by the gut microbiome and metabolome analysis, providing new insights into rejection mechanisms and identifying new approaches for clinical renal allograft rejection diagnosis.