Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms.

• Tác giả: Batool Arif, Andrea Bredemeyer, Christophe Combadière, Lisa Detering, Santiago Elizondo-Benedetto, Sean J English, Xuefeng Gao, Robert J Gropler, Kitty Harrison, Gyu Seong Heo, Joseph Ippolito, Yeona Kang, Richard Laforest, Kory Lavine, Chieh-Yu Lin, Yongjian Liu, Hannah Luehmann, Laura McDonald, Sergio Sastriques-Dunlop, Deborah Sultan, Dakkota Thies, Mohamed S Zaghloul, Mohamed A Zayed, Xiaohui Zhang, Jie Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 598.4175 Miscellaneous orders of water birds
• Thông tin xuất bản: United States : JACC. Basic to translational science , 2025
• Bộ sưu tập: NCBI
• ID: 743782

Tóm tắt

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a high mortality upon rupture. There is no diagnosis to predict the rupture nor effective medical therapies to prevent rupture. Here we demonstrate that the C-C chemokine receptor type 2 (CCR2) is a theranostic biomarker for AAA. In rat AAA models, we determined the potential of a CCR2-targeted positron emission tomography radiotracer [