INTRODUCTION: Managing recurrent atrial flutter (AFL) following radiofrequency ablation (RFA) for atrial fibrillation (AF) poses significant clinical challenges. METHODS AND RESULTS: We report an 82-year-old male with mirror-image dextrocardia who developed AFL post-AF ablation. During the redo procedure, vein of Marshall ethanol infusion (VOM-Et) was employed as the initial intervention, successfully terminating the mitral isthmus (MI)-dependent AFL and transitioning into cavotricuspid isthmus (CTI)-dependent AFL during ethanol infusion. Subsequent ablation restored sinus rhythm. CONCLUSION: Using VOM-EI as the initial intervention in patients with recurrent AFL is a feasible and safe approach, and to our knowledge, this represents the first reported case of VOM-EI in a patient with recurrent AFL in the setting of dextrocardia.