We aimed to estimate SARS-CoV-2 seropositivity among children and young people in Lomé, Togo, according to HIV status. A multicenter comparative cross-sectional study was conducted, and 636 participants were included (41.8% living with HIV). Anti-S (88.7% vs. 89.1%) and anti-N (41.6% vs. 39.5%) IgG seropositivity were comparable in both groups. These data suggest no increased COVID-19 susceptibility in children and young people with HIV.