PURPOSE: To evaluate the clinical efficacy of advanced platelet-rich fibrin(A-PRF) and concentrated growth factor(CGF) combined with nano-hydroxyapatite in external maxillary sinus lift implantation. METHODS: A total of 68 patients who underwent external maxillary sinus lift implantation from April 2023 to March 2024 at Taikang Xianlin Gulou Hospital were selected. They were randomly assigned to the control group(n=34, using Bio-Oss large particle bone graft material) and combined group(n=34, using A-PRF and CGF combined with nano-hydroxyapatite). Postoperative symptoms, bone levels, wound healing status, stability coefficient, mucosal healing, and complications were compared between the two groups. SPSS 27.0 software package was used for statistical analysis of the data. RESULTS: At 1 month and 3 months after operation, the conscious symptom score in combination group was significantly lower than that in the control group (P＜0.05), bone mineral density, bone increment and bone height at 6 months after operation were significantly lower than those in the control group
ISQ value, keratinized gingiva width and thickness were significantly higher than those in the control group (P＜0.05). The primary healing rate I in combination group was higher than that in the control group, and the healing time was lower than that in the control group(P＜0.05). There was no significant difference in the occurrence of adverse events between the combined and control groups(P＞0.05). CONCLUSIONS: The combination of A-PRF and CGF with nano-hydroxyapatite significantly improves bone quality, enhances implant stability, and accelerates postoperative recovery in external maxillary sinus lift implantation.