Clinical Practice of Poly (ADP-Ribose) Polymerase Inhibitors for Maintenance Treatment of Platinum-Sensitive Recurrent Ovarian Cancer in China.

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Tác giả: Xi Chen, Junjie Hong, Zhuyan Shao, Qiang Wen, Wen Yu, Haifei Zhou, Tao Zhu, Yuyang Zhu

Ngôn ngữ: eng

Ký hiệu phân loại: 333.822 Coal

Thông tin xuất bản: England : BJOG : an international journal of obstetrics and gynaecology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 743890

Clinical trials of three poly (ADP-ribose) polymerase (PARP) inhibitors, olaparib, niraparib and fuzuloparib, in platinum-sensitive recurrent ovarian cancer (PSR OC) in China showed that PARP inhibitors improved progression-free survival and achieved an all-comer indication in this population. We reviewed the efficacy and safety of these PARP inhibitors in patient populations studied in clinical trials and highlighted the positive role of PARP inhibitors in improving patient outcomes using clinical trials and real-world studies conducted in China. This article also discusses the issues encountered in clinical practice and how to evaluate the different indications for PSR OC in China and abroad.
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