Transcriptional Signatures of the Right Ventricle in End-Stage Heart Failure.

• Tác giả: Tarek Absi, Vineet Agrawal, Evan L Brittain, Giovanni E Davogustto, Jonah D Garry, Anna Hemnes, Yan Ru Su, Kelsey Tomasek, James D West, Fei Ye
• Ngôn ngữ: eng
• Ký hiệu phân loại: 611.018166 Human anatomy, cytology, histology
• Thông tin xuất bản: United States : Pulmonary circulation , 2025
• Bộ sưu tập: NCBI
• ID: 743940

Tóm tắt

The molecular mechanisms driving right ventricular (RV) adaptation to stress and failure in end-stage heart failure (HF) are largely unknown. We aimed to characterize myocardial transcriptional changes in the RV caused by left sided HF and comparing RV compensation to failure. Additionally, we compared transcriptomic changes between right and left ventricular (LV) failure. Paired right and left ventricular myocardial tissue samples were obtained from 33 human subjects with end stage HF referred for transplantation and 8 control donors with unused transplant hearts. RV samples from end stage HF subjects were subdivided into compensated (