dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction.

• Tác giả: Pak-Hin Hinson Cheung, Li Wu, Hua Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 152.142 Spatial perception
• Thông tin xuất bản: United States : Journal of virology , 2025
• Bộ sưu tập: NCBI
• ID: 743970
• Chủ đề: 1. Dntp; 2. Depletion; 3. And

Tóm tắt

SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.