Single-cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus.

• Tác giả: Seth L Alper, Steven E Arnold, Diane Chan, Phan Q Duy, Baojian Fan, Carla Fortes, Matthew P Frosch, Ana B W Greenberg, Le T Hao, Bradley T Hyman, Kristopher T Kahle, Emre Kiziltug, Ani Manichaikul, Guy M McKhann, Neel H Mehta, Susan Mullany, Andrew F Teich
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.11244 Engineering mechanics and materials
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 744096

Tóm tắt

We have generated a single-cell RNA sequencing atlas of peripheral blood and ventricular CSF in idiopathic normal pressure hydrocephalus (iNPH) patients totaling 140,207 single-cell transcriptomes. We found proinflammatory alterations in peripheral blood and CSF monocytes in iNPH patients with lower baseline cognitive function. We also identified CSF cell populations likely representing periventricular sloughing of degenerating neuroglial cells. Our findings suggest possible immune dysregulation in the blood and CSF of iNPH patients.