Harnessing visible light for metal-free trifluoromethylation/cyclization of unactivated alkenes.

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Tác giả: Heng Li, Chenwei Liu, Xiaowen Qin, Shuhui Sun, Tiefeng Xu, Zhiping Yin, Weiheng Yuan

Ngôn ngữ: eng

Ký hiệu phân loại: 359.9 Specialized combat forces; engineering and related services

Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 744172

Visible light-driven radical trifluoromethylation/cyclization of unactivated alkenes offers a sustainable alternative to conventional methods for constructing chroman-4-one and related heterocyclic scaffolds. Herein, we report a metal-free photocatalytic system utilizing rhodamine B as an organic photocatalyst and Togni II reagent as a trifluoromethyl source. This mild protocol enables efficient intramolecular tandem cyclization, affording diverse chroman-4-ones, dihydroquinolin-4-ones, and 1-indanones (24-69% yields) with broad functional group tolerance. The operational simplicity and avoidance of transition metals highlight the synthetic utility of this approach.
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