A novel peptide targeting PD-1: implications for protein-protein interaction studies and immunotherapy.

• Tác giả: Satya Prakash Arya, Raunak Jahan, Rick Mason Postema, Andrew Michael Reynolds, Xiaohong Tan, Siddhartha Kalpa Samadhi Thennakoon, Hari Timilsina
• Ngôn ngữ: eng
• Ký hiệu phân loại: 302.222 Nonverbal communication
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 744180

Tóm tắt

Chemical ligand binding to PD-1 is a powerful approach for studying protein-protein interactions and advancing immunotherapy. In this study, we introduce a novel II peptide with strong binding affinity for PD-1. Molecular docking analysis reveals key interactions between the II peptide and PD-1, supporting inhibition ELISA data and indicating that the II peptide overlaps with the PD-1/PD-L1 interaction interface.