Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pK

• Tác giả: Aimée Bugler-Lamb, Yong Chen, Jamie De Baere, Bruno G De Geest, Emily De Lombaerde, Kim Deswarte, Claudia M Brenis Gomez, Mark Gontsarik, Martin Guilliams, Bart N Lambrecht, Heleen Lauwers, Niek N Sanders, Martijn J Schuijs, Zifu Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 497.315 Miami
• Thông tin xuất bản: Germany : Angewandte Chemie (International ed. in English) , 2025
• Bộ sưu tập: NCBI
• ID: 744235

Tóm tắt

Lipid nanoparticles (LNPs) are currently the most clinically advanced mRNA delivery vectors. However, optimizing LNPs for in vivo applications remains largely empirical. The apparent pKa of LNPs is a predictive factor for in vivo performance, with pK