INTRODUCTION: A new series of triazoles with antifungal activity have been synthesized in a one-step fashion by direct reaction of 2-(2,4-difluorophenyl)-2,3-epoxy-1-(1H-1,2,4-triazol-1-yl)propane with various diamines. METHOD: Obtained compounds were profiled for biological activity against pathogenic strains of fungi C. albicans and A. niger. Molecular modeling was used to predict binding modes. RESULT: The lead compound was 4 times more active against C. albicans than fluconazole and demonstrated a wider spectrum of activity, inhibiting the growth of A. niger. CONCLUSION: The results presented herein can contribute to the development of novel antifungal therapeutic agents.