Mechanically driven catalysis (MDC) has emerged as an effective strategy for environmental remediation, renewable energy conversion, and cancer therapy
this functions by converting mechanical forces to drive catalytic reactions. This review examines four primary mechanisms, namely, piezocatalysis, flexocatalysis, tribocatalysis, and sonocatalysis, each involving specific catalytic pathways for harnessing mechanical energy at the nanoscale. However, significant challenges arise in decoupling the effects related to each individual mechanism in order to better understand and manipulate their synergies. In this review, the fundamental principles underpinning MDC are systematically interpreted. Beyond mechanistic insights, recent advancements in performance enhancement strategies for these catalysts are highlighted. Potential applications using these mechanistic approaches in environmental remediation (pollutant and antibiotic degradation and microbial disinfection), renewable energy conversion (hydrogen production and greenhouse gas conversion), and biomedical treatments (particularly cancer therapy) are discussed. Finally, the mechanistic synergies and limiting factors are explored, addressing challenges related to the overlooked combined effects of ultrasound as the activation source, complexities in mechanical force interactions at the nanoscale, and the need for targeted application strategies. Additionally, the industrial potential of these catalytic processes with consideration to scalability and practical deployment is evaluated. While challenges remain, this review provides a roadmap for advancing mechanically driven catalyst design and implementation toward real-world applications, offering potential into its future trajectory and transformative impact across numerous fields.