Normal Residual Lymphoid Cell Populations in Blood as Surrogate Biomarker of the Leukemia Cell Kinetics in CLL BinetA/Rai 0.

• Tác giả: Julia Almeida, Teresa Contreras, Ignacio Criado, Blanca Fuentes Herrero, Carlos Gomez-Gonzalez, Ana Lerma-Verdejo, Iryna Luts, María Dolores Martinez-Moya, Nahir Moreno, Guillermo Oliva-Ariza, Alberto Orfao, Jose Manuel Serrano-Lozano, Fernando Solano, Cristina Teodosio
• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.471 Cell respiration in animals
• Thông tin xuất bản: Switzerland : Cancers , 2025
• Bộ sưu tập: NCBI
• ID: 74471

Tóm tắt

 Despite the current international prognostic index for chronic lymphocytic leukemia (CLL) being widely accepted and broadly used, it does not consider the kinetics of the B-cell clone over time. Here, we investigated the potential association between distinct features of leukemic cells and other immune cells in blood and the kinetics of clonal B-cells in CLL stage Binet A/Rai 0 (A/0) patients
  Methods: Based on the leukemia cell kinetics, 69 CLL A/0 cases followed for a median of 105 months were classified as carrying stable (