Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain.

• Tác giả: Azadeh Aryan, James K Biedler, Karthikeyan Chandrasegaran, Austin Compton, Melanie Hempel, Mark B Potters, Atashi Sharma, Zhijian Tu, Clément Vinauger
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 745495

Tóm tắt

Diverse genetic strategies are being pursued to control mosquito-borne infectious diseases. These strategies often rely on the release of nonbiting males to either reduce the target mosquito population or render them resistant to pathogens. Male-only releases are important as any contaminating females can bite and potentially transmit pathogens. Despite significant efforts, it remains a major bottleneck to reliably and efficiently separate males from females, especially when nontransgenic males are preferred. In the yellow fever mosquito