In Situ Generation of Pyroptosis Inducer Mediated by Intracellular Labile Copper Pool for Safe and Robust Antitumor Immunotherapy.

• Tác giả: Fang Pu, Xiaogang Qu, Jinsong Ren, Anjun Song, Mengyu Sun, Wenjie Wang, Lu Zhang, Yanjie Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.1293 Military life and customs
• Thông tin xuất bản: United States : ACS nano , 2025
• Bộ sưu tập: NCBI
• ID: 745546
• Chủ đề: 1. In; 2. Situ; 3. Generation

Tóm tắt

Pyroptosis has garnered increasing interest in the realm of cancer immunotherapy. Utilizing reactive oxygen species (ROS) to trigger oxidative stress is considered an effective strategy for promoting pyroptosis. However, existing catalytic nanoparticles used as pyroptosis inducers contain heavy metals, which inevitably cause potential side effects on normal tissues due to their high toxicity and off-target effects. Herein, a labile copper pool-mediated in situ pyroptosis inducer was designed and developed using a hydrogen-bonded organic framework (HOF)-based nanoplatform to achieve safe and robust antitumor immunotherapy. The nanoplatform could target mitochondria and elevate labile Cu