OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate.

• Tác giả: Xueqing Ba, Istvan Boldogh, Zixu Cui, Jiakun Ge, Jinling Han, Yinchao Hu, Zhihua Ji, Chunshuang Li, Xining Li, Yusaku Nakabeppu, Zsolt Radak, Miaomiao Tian, Dapeng Wang, Jing Wang, Min Wei, Yaoyao Xue, Meichen Zhang, Haiwang Zhao, Jianyi Zhao, Xu Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 398.353 Human body, personality, qualities, activities
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 745557

Tóm tắt

8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant