Modular Access to Fluorinated Quaternary Stereocenters via Palladium/Lewis Base Synergistic Catalysis.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Zitong Lin, Rixin Liu, Thomas N Snaddon, Qinglong Zhang, Weiwei Zi

Ngôn ngữ: eng

Ký hiệu phân loại: 005.112 +*Modular programming

Thông tin xuất bản: Germany : Angewandte Chemie (International ed. in English) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 745587

The stereocontrolled construction of fluorinated quaternary stereocenters in acyclic systems remains a significant synthetic challenge. We report a synergistic palladium/Lewis base catalytic platform that directly couples α-fluoro-α-aryl acetates with allenes or 1,3-dienes without directing groups. This strategy overcomes traditional limitations in fluoronucleophile activation and stereochemical control, enabling access to diverse acyclic fluorinated architectures. Key to success is the use of axial-chiral Lewis bases, which work cooperatively with palladium catalysts to govern both enantioselectivity and diastereoselectivity. The method accommodates broad substrate scope, including aromatic, heterocyclic, and aliphatic systems, while demonstrating scalability and synthetic versatility through downstream transformations. This work not only bridges essential voids in fluorinated stereochemical space but also enhances the practical applications of synergistic catalyst systems.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH