Association of RDoC dimensions with

• Tác giả: Sabina Berretta, Shu Dan, Peter Durning, Weiqian Jiang, Torsten Klengel, Thomas H McCoy, Jonathan Vogelgsang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 286.136 *American Baptist Association
• Thông tin xuất bản: United States : Alzheimer's & dementia (Amsterdam, Netherlands) , 2025
• Bộ sưu tập: NCBI
• ID: 745677

Tóm tắt

 INTRODUCTION: Neuropsychiatric symptoms are common in people with Alzheimer's disease (AD) across all severity stages. Their heterogeneous presentation and variable temporal association with cognitive decline suggest shared and distinct biological mechanisms. We hypothesized that specific patterns of gene expression associate with distinct National Institute of Mental Health Research Domain Criteria (RDoC) domains in AD. METHODS: Post-mortem bulk RNA sequencing of the insula and anterior cingulate cortex from 60 brain donors, representing the spectrum of canonical Alzheimer's disease neuropathology, was combined with natural language processing approaches based on the RDoC Clinical Domains to uncover transcriptomic patterns linked to disease progression. RESULTS: Distinct sets of >
 100 genes ( DISCUSSION: Our findings provide evidence for distinct transcriptional profiles associated with RDoC domains suggesting that each dimension is characterized by sets of genes providing insight into the underlying mechanisms.