Oncogenic fusions converge on shared mechanisms in initiating astroblastoma.

• Tác giả: Shanshan Chen, Rong Guo, Tong Guo, Zhenzhen Guo, Fuchuan Jia, Wenlong Li, Wei Shi, Yixing Shi, Qianqian Sun, Wenli Sun, Yu Xia, Xiangyu Xie, Yang Yu, Yangfan Zeng, Li Zhang, Xiangyu Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.959 *Anguinomorphoidea
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 745841

Tóm tắt

Chromosomal rearrangements and gene fusions are the initial events in the development of many cancers. Astroblastoma (ABM), a brain cancer of unknown cellular origin and challenging to treat, is associated with diverse in-frame gene fusions, including MN1-BEND2 and MN1-CXXC5 (refs.