BACKGROUND: Type 2 diabetes (T2D) is a considerable and growing burden in the Chinese population, and affected adults are at high risk of developing chronic kidney disease (CKD). This subgroup analysis of the FIGARO-DKD trial explored the cardiovascular and kidney benefits of finerenone in Chinese patients with CKD and T2D on optimized renin-angiotensin system blockade. METHODS: Patients with urine albumin-to-creatinine ratio (UACR) ≥30-<
300 mg/g and estimated glomerular filtration rate (eGFR) ≥25-≤90 mL/min/1.73 m RESULTS: A total of 325 Chinese patients were included. Finerenone resulted in a numerical decrease in the risk of the cardiovascular composite outcome (hazard ratio 0.91
95% confidence interval 0.50-1.67) and a significantly reduced risk of the key secondary kidney outcome (hazard ratio 0.48
95% confidence interval 0.29-0.79
CONCLUSIONS: Finerenone significantly reduced the composite kidney outcome, showed a trend to reduce cardiovascular outcomes, and demonstrated an acceptable safety profile in Chinese patients.