Age-Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All-Cause Mortality in a Sardinian Population Cohort.

• Tác giả: Francesco Cucca, Alessandro Delitala, Jun Ding, Edoardo Fiorillo, Myriam Gorospe, Sandra Lai, Edward G Lakatta, Michele Marongiu, Christopher H Morrell, Antonella Mulas, Richard Oppong, Marco Orru, Valeria Orru, Maria Grazia Piras, Yong Qian, David Schlessinger, Angelo Scuteri, Carlo Sidore
• Ngôn ngữ: eng
• Ký hiệu phân loại: 668.55 Cosmetics
• Thông tin xuất bản: England : Journal of the American Heart Association , 2025
• Bộ sưu tập: NCBI
• ID: 745879

Tóm tắt

 BACKGROUND: Growth differentiation factor 15 (GDF-15) levels are emerging as a candidate biomarker of aging. The present study aimed to: (1) characterize the association of GDF-15 with the continuum of arterial stiffening, assessed as carotid-femoral pulse wave velocity, as age increases
  (2) determine the predictive role of serum GDF-15 levels on mortality
  and (3) identify genetic determinants of serum GDF-15 levels. METHODS AND RESULTS: Serum levels of GDF-15 and established cardiovascular risk factors, including pulse wave velocity, were assessed in a large (4736 individual) Sardinian population. Serum levels of GDF-15, which can be reliably measured repeatedly over time, increase with age
  are associated with a stiffer aorta
  "mediate" a large proportion of the age-associated increase in arterial stiffness
  pose risks because of their association with greater mortality
  and are significantly associated with the variant rs11549407, which causes thalassemia major in homozygosity. CONCLUSIONS: Because of its consistent ability to predict functional and clinical outcomes, including all-cause mortality, we conclude that GDF-15 serum levels serve as a robust biomarker for the continuum from health to the emergence of clinical disease during aging and, subsequently, to the likelihood of mortality.